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Clinical and Research Report |
Received February 24, 1997; revised August 10, 1997; accepted August 11, 1997. From the Department of Psychiatry, University of California, San Diego, and the San Diego Veterans Affairs Medical Center. Address correspondence to Dr. Jeste, Psychiatry Service, 116A1, Veterans Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, e-mail: Dilip_Jeste{at}GP-Post.ucsd.edu
Elderly patients with schizophrenia and dementia patients with agitation are frequently candidates for antipsychotic treatment. Conventional neuroleptics have relatively little effect on negative symptoms and may cause considerable side effects, especially in elderly patients. The authors have found a 29% cumulative annual incidence of tardive dyskinesia (TD) in middle-aged and elderly outpatients treated with relatively low doses of conventional neuroleptics. Newer antipsychotics are less likely to cause extrapyramidal symptoms and may be associated with a lower risk of TD. They are generally effective for both positive and negative symptoms and may also improve some aspects of cognition, but these drugs have their own side effects. Dosing requirements for elderly patients tend to be much lower than those for younger adults.
Key Words: Antipsychotics • Pharmacotherapy • New Drugs
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