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Am J Geriatr Psychiatry 9:393-399, November 2001
© 2001 American Association for Geriatric Psychiatry

Regular Article

Estrogen Replacement Therapy and Antidepressant Response to Sertraline in Older Depressed Women

Lon S. Schneider, M.D., Gary W. Small, M.D., and Cathryn M. Clary, M.D.

Received February 8, 2001; revised April 4, 2001; accepted April 18, 2001. From the Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, the Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, and Pfizer, Inc., New York, NY. Address correspondence to Dr. Schneider, 1975 Zonal Ave, KAM-400, Los Angeles, CA 90033. e-mail: lschneid{at}hsc.usc.edu

The influence of the use of estrogen replacement therapy (ERT) on the antidepressant response to sertraline of 127 women over 60 years old was evaluated with data from two multicenter trials. At endpoint, sertraline-treated women taking ERT had significantly greater global improvement and quality of life than those not receiving ERT. Modest improvements were also observed in anxiety symptoms and cognitive functioning. The results provide preliminary evidence that ERT use (without progesterone) in older depressed women may augment the antidepressant response to sertraline in terms of quality of life and general improvement.

Key Words: Depression • Antidepressants • Hormone Replacement Therapy • Sertraline




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