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The Influence of Age on the Response of Major Depression to Electroconvulsive Therapy

A C.O.R.E. Report

Received April 5, 2001; revised May 25, 2001; accepted June 4, 2001. From the Mayo Clinic, Rochester, Minnesota. Address correspondence to Dr. O'Connor, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

As part of a C.O.R.E., multi-site longitudinal study comparing continuation electroconvulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, 65 years; 46–64 years; and 45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

Key Words: Depression • ECT • Age Variables

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