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Longitudinal Study of Quality of Life in People with Advanced Alzheimer's Disease

Received March 22, 2000; revised June 2, 2000; accepted July 12, 2000. From the Gertrude H. Sergievsky Center and Department of Neurology, Columbia University, New York, NY. Address correspondence to Dr. Albert, Gertrude H. Sergievsky Center, P&S Box 16, PH-19, Columbia University, 630 West 168th St., New York, NY 10032. e-mail: sma10{at}columbia.edu

The authors examined three indicators of health-related quality of life in people with advanced Alzheimer's disease ([AD]; N=150): confinement to home, null activity, and null positive affect, as reported by patient proxies. Dementia severity predicted time-to-onset for all three disease milestones in models that controlled for sociodemographic indicators, nursing home status, and death in the follow-up period. Patients whose dementia worsened over follow-up were more likely to reach each milestone. These outcomes represent key milestones in the care of patients; they are sensitive to disease progression, and they are likely to be useful for studying treatment in advanced AD.

Key Words: Alzheimer Disease • Longitudinal Approaches • Quality-of-Life Issues

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