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Investigations Into Geriatric Psychiatry Challenges

AAGP Senior Investigator Award 2000

Received January 10, 2000; accepted March 2, 2000. From the Department of Psychiatry and Biobehavioral Sciences, the Neuropsychiatric Institute, the Alzheimer's Disease Center, and the Center on Aging, University of California at Los Angeles; and the VA Greater Los Angeles Healthcare System, Los Angeles, CA. Address correspondence to Dr. Small, UCLA Neuropsychiatric Institute, Room 88-201, 760 Westwood Plaza, Los Angeles, CA 90024-1759. e-mail: gsmall{at}mednet.ucla.edu

The author summarizes the American Association for Geriatric Psychiatry Senior Investigator Award presentation delivered at the 13th Annual Meeting March 12–15, 2000, in Miami Beach, Florida, and reviews his research studies that define a trajectory leading to investigations of early detection and prevention of Alzheimer's disease (AD). Themes and critical transitions that fostered the research are emphasized, and effective collaboration, mentoring, and timing are discussed. These studies have combined neuroimaging and genetic methods to identify subjects before they develop AD, so that interventions might delay dementia onset. The eventual goal is to translate the clinical research discoveries into modern clinical practice.

Key Words: Alzheimer's Disease • Neuroimaging • Genetic Research