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Am J Geriatr Psychiatry 8:254-256, August 2000
© 2000 American Association for Geriatric Psychiatry

Brief Report

Apolipoprotein-E {epsilon}4 Allele Frequency and Conferred Risk for Cuban Americans With Alzheimer's Disease

Steven Sevush, M.D., Gloria Peruyera, B.A., Fiona Crawford, Ph.D., and Michael Mullan, M.D., Ph.D.

Received May 7, 1999; revised October 6, 1999; accepted November 8, 1999. From the Departments of Psychiatry and Neurology, University of Miami School of Medicine, Miami, Florida. Address correspondence to Dr. Sevush, Department of Psychiatry, Suite 702, 1400 NW 10th Avenue, Miami, FL 33136.

The authors compared Apo-E {epsilon}4 frequencies for Cuban American and white non-Hispanic persons with and without Alzheimer's disease (AD). The Apo-E {epsilon}4 allele conferred as large a risk for AD in Cuban Americans as for white non-Hispanics, a finding that differs from those for Hispanic subjects as a whole.

Key Words: Alzheimer's Disease • Apolipoprotein-E • Immigrant Groups




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