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Effect of Nortriptyline and Paroxetine on Extrapyramidal Signs and Symptoms

A Prospective Double-Blind Study in Depressed Elderly Patients

Received March 16, 1999; revised June 15, 1999; accepted September 8, 1999. From the Geriatric Psychopharmacology Program, Department of Psychiatry, University of Pittsburgh School of Medicine. Address correspondence to Dr. Sweet, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213. e-mail: sweetra{at}msx.upmc.edu

Selective serotonin-reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) have been reported to induce extrapyramidal signs and symptoms (EPS). The authors examined the change from baseline EPS, measured by an objective rating scale, in a group of elderly depressed patients participating in an ongoing randomized, double-blind comparison of nortriptyline and paroxetine. Mild baseline EPS were present in both groups. After 6 weeks of antidepressant treatment, patients in the nortriptyline group showed a significant decrease in total EPS scores. Patients in the paroxetine group showed a similar decrease in EPS from baseline, which did not reach statistical significance. There was no significant difference between nortriptyline and paroxetine in the change in EPS.

Key Words: Depression • Antidepressants • Extrapyramidal Side Effects

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				D. C. Mamo, B. G. Pollock, B. Mulsant, P. R. Houck, S. Bensasi, M. C. Miller, M. S. Redfern, and C. F. Reynolds III Effects of Nortriptyline and Paroxetine on Postural Sway in Depressed Elderly Patients Am J Geriatr Psychiatry, April 1, 2002; 10(2): 199 - 205. [Abstract] [Full Text] [PDF]