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A Longitudinal Study of Apolipoprotein-E Genotype and Depressive Symptoms in Community-Dwelling Older Adults

Received February 11, 1999; revised June 1, 1999; accepted July 9, 1999. From the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, Stanford, California, and the VA Palo Alto Health Care System, Palo Alto, CA. Address correspondence to Dr. Murphy, Neuroscience Research Laboratories, Department of Psychiatry and Behavioral Sciences, MSLS P-104, Stanford University School of Medicine, Stanford CA 94305-5485. e-mail: greer.murphy{at}stanford.edu

The Apolipoprotein-E (APOE) 4 allele is a risk factor for Alzheimer's disease (AD) and cognitive decline in older adults. Depression may also be a risk factor for dementia, and depression is important in the differential diagnosis of dementia. The authors performed a 5-year longitudinal study of APOE genotype and change in Geriatric Depression Scale scores in 113 community-dwelling older adults. No association was observed between APOE genotype and change in depressive symptoms. These results do not support the hypothesis that the APOE 4 allele is associated with depression. Important objections have been raised to APOE genotyping in the diagnosis of AD. However, the specificity of APOE genotyping in AD diagnosis would not appear to be compromised by an association with depression.

Key Words: Apolipoprotein-E • Depression • Longitudinal Approaches

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