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Am J Geriatr Psychiatry 7:349-352, November 1999
© 1999 American Association for Geriatric Psychiatry

Clinical and Research Reports

The Effects of Donepezil on the P300 Auditory and Visual Cognitive Evoked Potentials of Patients With Alzheimer's Disease

Roy R. Reeves, D.O., Ph.D., Frederick A. Struve, Ph.D., Gloria Patrick, M.S., J. Gary Booker, M.D., and Dennis W. Nave, M.D.

Received August 7, 1998; revised October 23, 1998; accepted November 5, 1998. From the Departments of Psychiatry, VA Medical Center, Jackson, MS, Univ. of Miss. School of Med., and LSU (Shreveport) School of Medicine. Address correspondence to Dr. Reeves, Department of Psychiatry, VA Medical Center (116A), 1500 East Woodrow Wilson, Jackson, MS 39216.

Donepezil is a cholinesterase inhibitor used for the treatment of patients with mild to moderately severe Alzheimer's disease (AD). The purpose of this study was to determine the effect of treatment with donepezil 5 mg qd on cognitive evoked potentials (EPs) of patients with AD. Although treatment with donepezil did not normalize EP latencies, treatment was associated with a significant decrease in the auditory P300 latency (mean latency pretreatment=401.5 msec; posttreatment=392.7 msec.; P=0.04), and the visual P300 latency (mean latency pretreatment=605.7 msec; posttreatment=580.3 msec; P=0.04). Treatment with donepezil had no discernible effect on auditory or visual P300 EP amplitudes.

Key Words: Donepezil • Evoked Potentials • Alzheimer's Disease




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E. Katada, K. Sato, A. Sawaki, Y. Dohi, R. Ueda, and K. Ojika
Long-Term Effects of Donepezil on P300 Auditory Event-Related Potentials in Patients with Alzheimer's Disease
J Geriatr Psychiatry Neurol, March 1, 2003; 16(1): 39 - 43.
[Abstract] [PDF]


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Copyright © 1999 American Association for Geriatric Psychiatry