AJGP
HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a Colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Swanwick, G. R.J.
Right arrow Articles by Lawlor, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Swanwick, G. R.J.
Right arrow Articles by Lawlor, B. A.
Am J Geriatr Psychiatry 7:335-338, November 1999
© 1999 American Association for Geriatric Psychiatry

Brief Report

Prognostic Value of Electrophysiological Markers in Alzheimer's Disease

Gregory R.J. Swanwick, M.D., MRCPI, MRCPsych, Michael J. Rowan, Ph.D., Robert F. Coen, B.A., M.Sc., Davis Coakley, M.D., FRCPI, and Brian A. Lawlor, M.D., FRCPI, MRCPsych

Received July 14, 1998; revised December 2, 1998; accepted January 27, 1999. From Mercer's Institute for Research on Aging, St. James's Hospital, Dublin, Ireland. Address correspondence to Dr. Swanwick, Mercer's Institute for Research on Aging (MIRA), St. James's Hospital, James's Street, Dublin 8, IRELAND.

The authors assessed the usefulness of event-related potentials (ERP) and flash visual evoked potentials (FVEP) as prognostic markers in a sample of 25 subjects with probable Alzheimer's disease (AD). ERP and FVEP recordings were obtained from 21 and 23 subjects, respectively. Ranking of the annual rate of change in cognitive scales vs. baseline ERP/FVEP latencies was compared, and those with longer FVEP N2 component latencies showed slower subsequent rates of decline ({tau}=0.32; z=2.16; P=0.015), suggesting that further study of FVEP responses as prognostic markers in AD is warranted.

Key Words: Alzheimer's Disease • Research Techniques • Neurophysiology • Prognostic Evaluation






HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS
Copyright © 1999 American Association for Geriatric Psychiatry