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Alpha₁-Acid Glycoprotein, Age, and Sex in Mood Disorders

Received September 1, 1998; revised September 21, 1998; accepted January 19, 1999. From New York Presbyterian Hospital, Westchester Division, White Plains, NY, and The Joan and Sanford I. Weill Medical College of Cornell University, New York, NY. Address correspondence to Dr. Young, The New York Hospital Presbyterian Hospital–Cornell Medical Center, Department of Psychiatry, Westchester Division, 21 Bloomingdale Road, White Plains, NY 10605.

Serum alpha₁-acid glycoprotein (AAG) reportedly can increase with age in the normal population, especially among women. In 33 patients with unipolar major depression or bipolar disorder, serum AAG was measured by age. The authors noted a positive association with age, particularly in depressed female patients (n=18; r_s=0.61; P<0.01). The authors discuss implications for drug pharmacokinetics. Investigation of AAG in mood disorders needs to take age and sex into consideration.

Key Words: Mood Disorders • Neurophysiology • Antidepressants • Neuroleptics

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