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Received June 23, 1998; revised October 31, 1998; accepted December 8, 1998. From the Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, Departments of Psychiatry and Biostatistics, University of Rochester Medical Center, Rochester, NY. Address correspondence to Dr. Lyness, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd., Rochester, NY 14642; e-mail: Jeffrey_Lyness{at}urmc rochester. edu
The authors examined whether cerebrovascular risk factors (CVRFs) are associated with depressive diagnoses and symptoms in 303 primary-care patients age 
60 years, as would be consistent with a small-vessel brain disease model of later-life depression. CVRFs were not significantly independently associated with major, minor, or subsyndromal depression, late-onset major depression, or overall depressive symptom severity. These data did not support the notion that a small-vessel brain disease model of depression might apply to the majority of older persons with depressive symptoms and syndromes in primary-care settings. Future work should include longitudinal study with larger sample sizes.
Key Words: Depression • Cerebrovascular Factors • Syndromes Secondary to General Medical Disorders • Primary Care Patients
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