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Minor Depression After Stroke

An Initial Validation of the DSM-IV Construct

Received June 1, 1998; revised September 29, 1998; accepted October 21, 1998. From the Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, IA. Address correspondence to Dr. Paradiso, Department of Psychiatry MEB, The University of Iowa, Iowa City, IA 52242-1000. e-mail: sergio-paradiso @uiowa. edu

Using 141 patients with a single left- or right-hemisphere stroke, the authors investigated the distinction between major and minor depression after stroke. Major- and minor-depression patients and nondepressed control patients were compared, and a logistic-regression model suggested that major and minor depressions may be cross-sectionally distinguishable disorders. Minor depression was associated with younger age, left-hemisphere lesion location, and more caudal hemisphere lesions. There was an association between minor depression and pathoanatomical variables, with results generally consistent with the categorical vs. the continuum hypothesis of mood disorders in stroke victims. Authors discuss the significance of damage in left-hemisphere posterior portions of the brain for the development of minor depression after stroke.

Key Words: Depression • Stroke • DSM • Diagnostic Criteria

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