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Am J Geriatr Psychiatry 7:160-165, May 1999
© 1999 American Association for Geriatric Psychiatry

Regular Article

Examination of the Cognitive Effects of Cimetidine in Normal Elderly Volunteers

David W. Oslin, M.D., Ira R. Katz, M.D., Ph.D., Laura Prouty Sands, Ph.D., Warren Bilker, Ph.D., Suzanne D. DiFilippo, B.A., and Kristina D'Angelo, B.A.

Received May 7, 1998; revised August 31, 1998; accepted September 28, 1998. From the Section on Geriatric Psychiatry, University of Pennsylvania, Philadelphia, PA. Address correspondence to Dr. Katz, Section on Geriatric Psychiatry, University of Pennsylvania, 3600 Market St., Room 812, Philadelphia, PA 19104; e-mail: katzi{at}mail.med.upenn.edu

The authors evaluated the cognitive effects of acute challenges with the H2 receptor-antagonist cimetidine in normal older volunteers. The study was a double-blind, placebo-controlled, crossover study of 12 volunteers, average age 71.25 years. Baseline assessment was followed by randomized administration of a placebo or ascending doses of cimetidine (400 mg, 800 mg, or 1,600 mg) in test sessions separated by 1 week. Cognitive performance was evaluated with a 1-hour battery of tests beginning 90 minutes after administration of a single dose of drug (or placebo). There were no significant cognitive decrements associated with cimetidine. Despite numerous case reports of cognitive toxicity, this study found no observable decrements in cognitive performance in a group of healthy elderly subjects; therefore, case reports in the literature may be reporting effects for patients with specific impairments or sensitivities.

Key Words: Cognition • Cimetidine • Side Effects






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