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Am J Geriatr Psychiatry 7:147-150, May 1999
© 1999 American Association for Geriatric Psychiatry


Regular Article

Brain Morphology and Response to Nortriptyline in Geriatric Depression

Robert C. Young, M.D., Balu Kalayam, M.D., Draupathi E. Nambudiri, M.D., Tatsuyuki Kakuma, Ph.D., and George S. Alexopoulos, M.D.

Received May 21, 1997; revised October 26, 1997; accepted June 4, 1998. From The New York Hospital-Cornell Medical Center, Westchester Division, White Plains, New York, and Cornell Institute of Geriatric Psychiatry. Address correspondence to Dr. Young, New York Hospital-Cornell Medical Center, Westchester Division, 21 Bloomingdale Road, White Plains, NY 10605.

In geriatric patients with major depression (N=15), the authors compared response to treatment with nortriptyline as it relates to brain morphology assessed by computed tomography. There was a significant negative association between ventricle–brain ratio and response to nortriptyline (rs=–0.63; P=0.015).

Key Words: Depression • Nortriptyline • Neuroanatomy







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