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Risperidone in the Treatment of Elderly Patients With Psychotic Disorders

Received October 28, 1997; revised April 9, 1998; accepted May 5, 1998. From St. John's Episcopal Hospital, South Shore, Far Rockaway, New York. Address correspondence to Dr. Madhusoodanan, St. John's Episcopal Hospital, South Shore, 327 Beach 19th Street, Far Rockaway, NY 11691. Dr. Brecher is at Janssen Research Foundation, Titusville, NJ.

The authors evaluated the safety, tolerability, and efficacy of risperidone in 103 elderly patients (mean age, 71 years) with schizophrenia (75%) or schizoaffective disorder (25%). Using the Extrapyramidal Symptoms Rating Scale (ESRS), Positive and Negative Syndrome Scale (PANSS), and Clinical Global Impression (CGI) scale, they conducted a prospective, open-label, 12-week trial in 14 psychiatric centers in the United States. Patients' symptoms were assessed at baseline and over a 12-week period. At endpoint, ESRS scores were significantly reduced, as were PANSS total and subscale scores. There were no clinically significant changes in electrocardiograms, laboratory test results, or vital signs. Risperidone was well tolerated and efficacious in elderly patients with schizophrenia or schizoaffective disorder.

Key Words: Risperidone • Psychosis • Pharmacotherapy

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