AJGP
HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a Colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harwood, D. G.
Right arrow Articles by Duara, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harwood, D. G.
Right arrow Articles by Duara, R.
Am J Geriatr Psychiatry 7:119-123, May 1999
© 1999 American Association for Geriatric Psychiatry

Regular Article

Apolipoprotein-E (APO-E) Genotype and Symptoms of Psychosis in Alzheimer's Disease

Dylan G. Harwood, M.A., Warren W. Barker, M.A., M.S., Raymond L. Ownby, M.D., Ph.D., Peter St. George-Hyslop, M.D., and Ranjan Duara, M.D.

Received February 10, 1998; revised April 2, 1998; accepted May 8, 1998. From The Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center and the University of Miami School of Medicine, Miami, Florida. Address correspondence to Mr. Harwood, Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, 4300 Alton Rd., Miami Beach, FL 33140.

The authors examined the association of Apolipoprotein-E (APO-E) genotype to symptoms of psychosis and depression in 501 patients diagnosed with probable (n=343) or possible (n=158) Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. They observed the following APO-E genotypes: {epsilon}2/{epsilon}3 (n=19); {epsilon}2/{epsilon}4 (n=14); {epsilon}3/{epsilon}3 (n=228); {epsilon}3/{epsilon}4 (n=203); {epsilon}4/{epsilon}4 (n=37). In contrast to previous reports, the results did not indicate a relationship between either the {epsilon}4 allele or the {epsilon}2 allele and symptoms of mood disturbance in AD. However, an elevated risk for psychosis was shown, specifically, at the severe stage of cognitive impairment, among AD patients carrying the {epsilon}4 allele, after effects of age, gender, education, and level of cognitive impairment were controlled.

Key Words: Apolipoprotein-E • Alzheimer's Disease • Psychosis




This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A L Pritchard, J Harris, C W Pritchard, J Coates, S Haque, R Holder, P Bentham, and C L Lendon
The effect of the apolipoprotein E gene polymorphisms and haplotypes on behavioural and psychological symptoms in probable Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, February 1, 2007; 78(2): 123 - 126.
[Abstract] [Full Text] [PDF]

Home page
 AJGPHome page
B. Borroni, M. Grassi, C. Agosti, S. Archetti, C. Costanzi, C. Cornali, C. Caltagirone, L. Caimi, M. Di Luca, and A. Padovani
Cumulative Effect of COMT and 5-HTTLPR Polymorphisms and Their Interaction With Disease Severity and Comorbidities on the Risk of Psychosis in Alzheimer Disease
Am J Geriatr Psychiatry, April 1, 2006; 14(4): 343 - 351.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
D Craig, D J Hart, K McCool, S P McIlroy, and A P Passmore
Apolipoprotein E e4 allele influences aggressive behaviour in Alzheimer's disease
J. Neurol. Neurosurg. Psychiatry, September 1, 2004; 75(9): 1327 - 1330.
[Abstract] [Full Text] [PDF]

Home page
 PsychosomaticsHome page
M. M. Bassiony and C. G. Lyketsos
Delusions and Hallucinations in Alzheimer's Disease: Review of the Brain Decade
Psychosomatics, October 1, 2003; 44(5): 388 - 401.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
J. Clarimon, J. Bertranpetit, M. Boada, L. Tarraga, and D. Comas
HSP70-2 (HSPA1B) is Associated with Noncognitive Symptoms in Late-Onset Alzheimer's Disease
J Geriatr Psychiatry Neurol, September 1, 2003; 16(3): 146 - 150.
[Abstract] [PDF]

Home page
 AJGPHome page
I. Leroi, A. Voulgari, J. C.S. Breitner, and C. G. Lyketsos
The Epidemiology of Psychosis in Dementia
Am J Geriatr Psychiatry, February 1, 2003; 11(1): 83 - 91.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Scarmeas, J. Brandt, M. Albert, D. P. Devanand, K. Marder, K. Bell, A. Ciappa, B. Tycko, and Y. Stern
Association between the APOE genotype and psychopathologic symptoms in Alzheimer's disease
Neurology, April 23, 2002; 58(8): 1182 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
C.-Y. Liu, C.-J. Hong, T.-Y. Liu, K.-N. Lin, P.-N. Wang, C.-W. Chi, Y.-Y. Chuang, and H.-C. Liu
Lack of Association between the Apolipoprotein E Genotype and Depression in Alzheimer's Disease
J Geriatr Psychiatry Neurol, April 1, 2002; 15(1): 20 - 23.
[Abstract] [PDF]

Home page
 J Geriatr Psychiatry NeurolHome page
R. A. Sweet, M. I. Kamboh, S. R. Wisniewski, O. L. Lopez, W. E. Klunk, D. I. Kaufer, and S. T. DeKosky
Apolipoprotein E and Alpha-1-Antichymotrypsin Genotypes Do Not Predict Time to Psychosis in Alzheimer's Disease
J Geriatr Psychiatry Neurol, April 1, 2002; 15(1): 24 - 30.
[Abstract] [PDF]

Home page
 J. Neuropsychiatry Clin. Neurosi.Home page
D. E. Fujii and I. Ahmed
Risk Factors in Psychosis Secondary to Traumatic Brain Injury
J Neuropsychiatry Clin Neurosci, November 1, 2001; 13(1): 61 - 69.
[Abstract] [Full Text]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
C. Geroldi, N. M. Akkawi, S. Galluzzi, M. Ubezio, G. Binetti, O. Zanetti, M. Trabucchi, and G. B Frisoni
Temporal lobe asymmetry in patients with Alzheimer's disease with delusions
J. Neurol. Neurosurg. Psychiatry, August 1, 2000; 69(2): 187 - 191.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS
Copyright © 1999 American Association for Geriatric Psychiatry