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Current Issues in Depression in Parkinson's Disease

Received February 20, 1998; revised June 2, 1998; accepted June 22, 1998. From the Parkinson's Disease and Movement Disorders Center, Tampa, Florida. Address correspondence to Dr. Hauser, Parkinson's Disease and Movement Disorders Center, University of South Florida College of Medicine, 4 Columbia Drive, Suite 410, Tampa, FL 33606.

Depression affects 40%–50% of Parkinson's disease (PD) patients. The authors, by use of a Mednet and manual search of pertinent literature, summarize current issues in the treatment of depression in PD. Open-label studies suggest that antidepressants may be effective for treating depression in PD. Although case reports indicate that selective serotonin reuptake inhibitors (SSRIs) can potentially worsen the motor symptoms of PD, this effect has not been confirmed in the small number of open-label studies that have been performed to date. The occurrence of the serotonin syndrome resulting from a combination of selegiline and an SSRI appears to be rare. Double-blind prospective studies are needed to evaluate the safety and efficacy of antidepressants in PD and their effect on motor function.

Key Words: Parkinson's Disease • Depression • Antidepressants

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