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Age at Onset in Geriatric Bipolar Disorder

Effects on Clinical Presentation and Treatment Outcomes in an Inpatient Sample

Received September 17, 1997; revised February 9, 1998; accepted February 24, 1998. From the Mental Health Clinical Research Center for Late-Life Mood Disorders (MH52247) and the Mental Health Clinical Research Center for Affective Disorders (MH30915), Department of Psychiatry, University of Pittsburgh Medical Center. Address correspondence to Dr. Wylie, Office 740-BT, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213.

The authors report on 62 inpatients over age 60 who met DSM-III-R criteria for bipolar disorder, divided into early- and late-onset groups by their median age at lifetime onset, 49 years, in order to examine differences in demographic and clinical characteristics, treatment parameters, and outcome in the two groups during a short-term hospitalization. The late-onset group was more likely to have psychotic features and to demonstrate cerebrovascular risk/burden. However, both groups had similar and highly significant improvements in the Brief Psychiatric Rating Scale, Global Assessment Scale, and the Mini-Mental State Exam, and 87% were able to be discharged to settings no more restrictive than those at admission.

Key Words: Bipolar Disorder • Age at Onset • Inpatients • Treatment Outcome

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