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Higher Cerebrospinal Fluid MHPG in Subjects With Dementia of the Alzheimer Type

Relationship With Cognitive Dysfunction

Received March 11, 1997; revised August 10, 1997; accepted September 15, 1997. From the Departments of Psychiatry and Neurology, Washington University School of Medicine. Address correspondence to Dr. Sheline, Departments of Psychiatry and Neurology, Washington University School of Medicine, Box 8134, 4940 Children's Place, St. Louis, MO 63110.

The authors sought to determine the relationships between cerebrospinal fluid (CSF) levels of three neurotransmitter monoamine metabolites and cognitive function. CSF was collected from subjects with dementia of the Alzheimer's type ([DAT] n=28) and control subjects (n=10) for determination of CSF 5-hydroxyindole acetic acid (5-HIAA), 3-methoxy-4-hydroxy-phenylglycol (MHPG), and homovanillic acid (HVA) levels. All subjects underwent systematic assessment to determine cognitive function. Subjects with DAT had higher concentrations of CSF MHPG. In the overall sample, cognitive function was inversely correlated with CSF levels of MHPG but not with 5-HIAA or HVA. Within the DAT sample, these correlations did not achieve significance.

Key Words: MHPG • Alzheimer's Disease • Dementia • Cerebrospinal Fluid