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Long-Term ECG Changes in Depressed Elderly Patients Treated With Nortriptyline

A Double-Blind, Randomized, Placebo-Controlled Evaluation

Received January 27, 1997; revised May 13, 1997; accepted June 26, 1997. From the Mental Health Clinical Research Center for the Study of Late-Life Mood Disorders (MHCRC/LLMD), Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania. Address correspondence to Dr. Reynolds, Mental Health Clinical Research Center for the Study of Late-Life Mood Disorders (MHCRC/LLMD), Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213.

ECGs of 50 patients who completed a long-term nortriptyline (NT) study are presented at baseline, after 7 weeks on NT, and after 1 year. The ECGs of patients with preexisting cardiac disease were compared with non-cardiac patients. Significant ECG changes and increases in heart rate were observed by Week 7 and persisted at a mean of 55 weeks (range: 24–111) in patients who were continued on NT. No significant difference was found in long-term ECG effects in patients with preexisting cardiac disease; ECG changes reverted to baseline when placebo was substituted. Patients with known cardiac disease did not show significantly worse ECG changes on NT than non-cardiac patients.

Key Words: Geriatric Depression • ECG Changes • Nortriptyline

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