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Am J Geriatr Psychiatry 6:53-58, February 1998
© 1998 American Association for Geriatric Psychiatry

Regular Article

Characterization of Depression in Alzheimer's Disease by the CERAD Behavior Rating Scale for Dementia (BRSD)

Michelle R. Jacobs, M.A., Milton E. Strauss, Ph.D., Marian B. Patterson, Ph.D., and James L. Mack, Ph.D.

Received January 15, 1997; revised May 8, 1997; accepted June 26, 1997. From the Alzheimer Center, Department of Neurology, University Hospitals of Cleveland, and Departments of Psychology, Neurology, and Psychiatry, Case Western Reserve University, Cleveland, Ohio. Address correspondence to Ms. Jacobs, University Alzheimer Center, 12200 Fairhill Road, Cleveland, OH 44120. Requests for the BRSD should be addressed to Albert Heyman, M.D., CERAD, Duke University Medical Center, Box 3203, Durham, NC 27710.

The authors selected 69 participants from an Alzheimer's disease research registry and diagnosed them as depressed or nondepressed by use of a semi-structured clinical interview. Responses to selected BRSD items were compared between the depressed and nondepressed groups. Differences between responses of the two groups on BRSD items related to anxiety and depression were significant. The groups did not significantly differ in their responses to items related to other content areas. On the basis of their responses to the BRSD anxiety and depression items, 70% of participants were correctly classified as depressed or nondepressed.

Key Words: Geriatric Depression • Dementia • Alzheimer's Disease




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