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Am J Geriatr Psychiatry 5:83-87, February 1997
© 1997 American Association for Geriatric Psychiatry
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Clinical and Research Report

Fluoxetine Discontinuation in Elderly Dysthymic Patients

D. P. Devanand, M.D., Min Kyung Kim, B.A., and Mitchell S. Nobler, M.D.

A group of 23 elderly outpatients with dysthymic disorder participated in a 13-week fluoxetine trial. Twelve re-sponders received open continuation treatment and subsequently discontinued fluoxetine (mean: 32 weeks on medication). During the 24 weeks after discontinuation, 6 of the 12 patients relapsed. Clinical features, dose, and duration of fluoxetine treatment were not predictive of relapse. The 50% relapse rate in this small sample is lower than that reported in young adult dysthymic patients but is high enough to warrant clinical caution.






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