HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Pollock, B. G. Articles by Rosen, J. Search for Related Content PubMed PubMed Citation Articles by Pollock, B. G. Articles by Rosen, J.

An Open Pilot Study of Citalopram for Behavioral Disturbances of Dementia Plasma Levels and Real-Time Observations

Citalopram, in European studies, has shown some early promise for treatment of poststroke depression and behavioral complications of dementia. An open pilot study of citalopram was conducted in 16 patients with dementia and behavioral disturbances. Citalopram was well tolerated by 13 of the patients, and 9 had a clinically impressive response. A significant overall mean reduction in disruptive vocalizations was observed by means of a novel technique of computer-assisted real-time observation. The mean citalopram plasma level-to-dose ratio was found to be twice that previously reported in younger patients. These pilot findings should encourage future placebo concentration-controlled trials.

This article has been cited by other articles:

				O. C. Gleason, W. R. Yates, M. A. Philipsen, M. D. Isbell, and B. G. Pollock Plasma Levels of Citalopram in Depressed Patients With Hepatitis C Psychosomatics, February 1, 2004; 45(1): 29 - 33. [Abstract] [Full Text] [PDF]

				D. W. Scharre, R. A. Davis, J. L. Warner, S.-I. Chang, and D. Q. Beversdorf A Pilot Open-Label Trial of Citalopram for Restless Activity and Aberrant Motor Behaviors in Alzheimer Disease Am J Geriatr Psychiatry, December 1, 2003; 11(6): 687 - 691. [Abstract] [Full Text] [PDF]

				F. H. Ramadan, B. J. Naughton, and R. Prior Correlates of Behavioral Disturbances and Pattern of Psychotropic Medication Use in Five Skilled Nursing Facilities J Geriatr Psychiatry Neurol, March 1, 2003; 16(1): 8 - 14. [Abstract] [PDF]

				O. L. Lopez, J. T. Becker, R. A. Sweet, W. Klunk, D. I. Kaufer, J. Saxton, and S. T. DeKosky Patterns of Change in the Treatment of Psychiatric Symptoms in Patients With Probable Alzheimer's Disease From 1983 to 2000 J Neuropsychiatry Clin Neurosci, February 1, 2003; 15(1): 67 - 73. [Abstract] [Full Text] [PDF]

				R. Moretti, P. Torre, R. M. Antonello, G. Cazzato, and A. Bava Depression and Alzheimer's disease: Symptom or comorbidity? American Journal of Alzheimer's Disease and Other Dementias, November 1, 2002; 17(6): 338 - 344. [Abstract] [PDF]

				B. G. Pollock, B. H. Mulsant, J. Rosen, R. A. Sweet, S. Mazumdar, A. Bharucha, R. Marin, N. J. Jacob, K. A. Huber, K. B. Kastango, et al. Comparison of Citalopram, Perphenazine, and Placebo for the Acute Treatment of Psychosis and Behavioral Disturbances in Hospitalized, Demented Patients Am J Psychiatry, March 1, 2002; 159(3): 460 - 465. [Abstract] [Full Text] [PDF]

				K. L. Lanctôt, N. Herrmann, and P. Mazzotta Role of Serotonin in the Behavioral and Psychological Symptoms of Dementia J Neuropsychiatry Clin Neurosci, February 1, 2001; 13(1): 5 - 21. [Abstract] [Full Text]

				K. Y. Kim, G. M. Bader, and E. Jones Citalopram for Verbal Agitation in Patients with Dementia J Geriatr Psychiatry Neurol, July 1, 2000; 13(2): 53 - 55. [Abstract] [PDF]

				F. H. Ramadan, B. J. Naughton, and A. G. Bassanelli Treatment of Verbal Agitation with a Selective Serotonin Reuptake Inhibitor J Geriatr Psychiatry Neurol, July 1, 2000; 13(2): 56 - 59. [Abstract] [PDF]