HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a Colleague Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sweet, R. A. Articles by Altieri, L. P. Search for Related Content PubMed Articles by Sweet, R. A. Articles by Altieri, L. P.

Neuroleptic-Induced Parkinsonism in Elderly Patients Diagnosed With Psychotic Major Depression and Dementia of the Alzheimer Type

Departments of Psychiatry and Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

The authors prospectively examined elderly patients diagnosed with major depression with psychotic features (MD-P) and patients diagnosed with dementia of the Alzheimer Type (DAT) for neuroleptic-induced parkinsonism (NIP) during perphenazine treatment. Baseline parkinsonian symptoms did not differ between groups. With treatment, mean NIP score doubled in DAT patients but remained unchanged in the MD-P group. The difference between groups was highly significant and remained so after the effects of age, perphenazine dose, and duration of perphenazine treatment were controlled. Although the mechanisms underlying these differences in NIP development remain to be determined, clinical guidelines for neuroleptic dosages in elderly patients need to account for variability in neuroleptic tolerance between diagnostic groups.

This article has been cited by other articles:

				D. C. Mamo, R. A. Sweet, B. H. Mulsant, B. G. Pollock, M. D. Miller, J. A. Stack, A. E. Begley, and C. F. Reynolds III Effect of Nortriptyline and Paroxetine on Extrapyramidal Signs and Symptoms: A Prospective Double-Blind Study in Depressed Elderly Patients Am J Geriatr Psychiatry, August 1, 2000; 8(3): 226 - 231. [Abstract] [Full Text]

				H. Lavretsky and D. Sultzer A Structured Trial of Risperidone for the Treatment of Agitation in Dementia Am J Geriatr Psychiatry, May 1, 1998; 6(2): 127 - 135. [Abstract] [Full Text]