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Memory Self-Appraisal and Cerebral Glucose Metabolism in Age-Associated Memory Impairment

From the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA) School of Medicine, and the Veterans Affairs Medical Center, West Los Angeles. Address correspondence to Dr. Small, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024–1759.

The authors used positron emission tomography to measure cerebral glucose metabolism in 43 people with age-associated memory impairment to determine relationships between memory self-appraisal and brain function. People with lower frontal metabolism during a resting state reported more frequent prior mnemonics usage, a measure of memory self-appraisal. A multiple regression analysis indicated that reported mnemonics usage was the most significant predictor of left (P = 0.0004) and right (P = 0.0014) frontal metabolism. These models indicated that mnemonics usage, along with depression ratings, accounted for 39% of left frontal lobe function and, along with visual spatial memory, accounted for 40% of right frontal metabolism. These results suggest that mnemonics usage may compensate for subtle frontal dysfunction or reflect greater efficiency of memory processing.

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