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A Study of Delusions in a Large Cohort of Alzheimer's Disease Patients

Departments of Psychiatry, Neurosciences, and Internal Medicine, University of California School of Medicine, and Vetenns Affairs Medical Center, La Jolla, CA.

The authors analyzed data on delusions and associated neuro-psychiatric symptoms in 1,229 consecutive patients with Alzheimer's disease (AD) at nine university-based State of California Alzheimer's Disease Diagnostic and Treatment Centers. Thirty-four percent of these patients had delusions. The delusional patients were older, more likely to be female, and had a later onset of AD than the nondelusional group. Compared to the nondelusional patients, the delusional patients also had more severe global cognitive impairment, along with a higher prevalence of hallucinations, agitation, depression, and gait disturbance, as well as family and marital difficulties and self-care problems.