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Preliminary Findings: Behavioral Worsening on Donepezil in Patients With Frontotemporal Dementia

From the Department of Neurology, University of California at Los Angeles, Los Angeles, CA.

Objective: The objective of this study was to evaluate donepezil, an acetylcholinesterase inhibitor, in the treatment of frontotemporal dementia (FTD).

Methods: Twelve patients with FTD who received donepezil for six months were compared with 12 FTD controls on behavioral measures.

Results: The groups did not differ on most variables at baseline or at six months; however, the donepezil group had greater worsening on the FTD Inventory. Four treated patients had increased disinhibited or compulsive acts, which abated with discontinuation of the medication.

Conclusion: There were no changes in global cognitive performance or dementia severity; however, a subgroup of patients with FTD can experience worsening of symptoms with donepezil.

Key Words: Frontotemporal dementia • donepezil • acetylcholinesterase inhibitors

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