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Am J Geriatr Psychiatry 14:803-807, September 2006
© 2006 American Association for Geriatric Psychiatry
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Brief Report

Paroxetine Treatment of Primary Insomnia in Older Adults

Charles F. Reynolds III, M.D., Daniel J. Buysse, M.D., Mark D. Miller, M.D., Bruce G. Pollock, M.D., Ph.D., Martica Hall, Ph.D., and Sati Mazumdar, Ph.D.

From the Advanced Center for Interventions and Services Research for Late-Life Mood Disorders (ACISR/LLMD) and the John A. Hartford Center of Excellence in Geriatric Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA (CFR, DJB, MDM, MH); Division of Geriatric Psychiatry, University of Toronto, Faculty of Medicine, The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada (BGP); and Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA (SM).

Objective: The goal of this study was to test the efficacy of paroxetine for primary insomnia in older adults.

Methods: Adults over age 55 with primary insomnia were randomly assigned to six weeks of double-blind treatment with paroxetine (N = 14) or placebo (N = 13). Outcome measures included persistence or resolution of insomnia; weekly diary measures of sleep quality, daytime alertness, and mood; and pre-/postpolysomnographic measures of sleep latency, wake time after sleep onset, and sleep efficiency.

Results: Although weekly diary-based measures showed improved subjective sleep quality, daytime alertness, and mood with paroxetine, the authors observed no effect on sleep efficiency or categorical response rates.

Conclusion: Paroxetine appears to be ineffective for treating primary insomnia in old age.

Key Words: Primary insomnia • antidepressant • paroxetine • old age






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