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Frontal Dysfunction Underlies Depressive Syndrome in Alzheimer Disease: A FDG-PET Study

From the Department of Neuropsychiatry and Clinical Research Institute (DYL, IHC, JIW), the Interdisciplinary Program of Cognitive Science (DYL, JIW), the Department of Nuclear Medicine (DSL, JSL, WJK), and the Neuroscience Research Institute of the Medical Research Center (JIW), Seoul National University, Seoul, Korea; the Department of Neuropsychiatry, Kangwon National University Hospital, Chuncheon, Korea (JHJ); the Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Kyunggi, Korea (KWK); the Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Yongin, Kyunggi, Korea (JCY); and the Department of Psychology, College of Social Science, Kangwon National University, Chuncheon, Korea (EJK).

Objective: This study aimed to investigate the regional cerebral dysfunction associated with depressive syndrome in patients with Alzheimer disease (AD).

Method: Twelve patients with AD with depressive syndrome (ADD) and 12 age-, gender-, and severity-matched patients with AD without depressive syndrome (ADND) underwent FDG-PET scanning. The regional cerebral glucose metabolism in the two groups was compared using a voxel-based method.

Results: The ADD group showed lower glucose metabolism in the right superior frontal gyrus than the ADND group.

Conclusions: These results indicate that frontal dysfunction, known to be associated with primary or other secondary depressive syndromes, underlies the depressive syndrome of patients with AD patients as well.

Key Words: Alzheimer's disease • depressive syndrome • frontal dysfunction • FDG-PET

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