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Caregiver Assessment of Patients’ Depression in Alzheimer Disease

Longitudinal Analysis in a Drug Treatment Study

Received May 4, 2004; revised August 8, November 12, 2004; accepted November 18, 2004. From Johns Hopkins University School of Medicine, Dept. of Psychiatry and Behavioral Sciences, Division of Geriatric Psychiatry and Neuropsychiatry, Baltimore, MD (PBR, CGL), Johns Hopkins Bloomberg School of Public Health, Center on Aging and Health, Baltimore, MD (MMM, CGL), and Johns Hopkins University School of Medicine, Alzheimer Disease Research Center, Baltimore, MD (MMM, CGL). Send correspondence and reprint requests to Paul B. Rosenberg, M.D., JHMI, 550 N. Broadway #308, Baltimore, MD 21205. e-mail: prosenb9{at}jhmi.edu
© 2005 American Association for Geriatric Psychiatry

Objective: Caregiver input is important in the assessment of depression in Alzheimer disease (AD), but depression and subjective burden can bias this input. Methods: In a 12-week, controlled, clinical trial of sertraline in depressed AD patients, authors correlated caregiver mood and subjective burden on several patient mood measures, incorporating varied degrees of caregiver input. Results: Caregiver variables accounted for up to 33% of the variance in patient mood ratings. Caregiver depression and burden decreased regardless of treatment assignment. Conclusion: Caregiver depression and burden affect their rating of AD patients’ mood, but the majority of variance is due to patient characteristics.

Key Words: Dementia • Alzheimer Disease • Caregivers • Depression • Antidepressants • Sertraline

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