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Predicting Cognitive Decline in Healthy Older Adults

Received October 8, 2004; revised December 13, 2004; accepted March 30, 2005. From OPTIMA, University of Oxford, Dept. of Pharmacology, Oxford UK (CDJ), University of Cambridge, School of Clinical Medicine, Dept. of Psychiatry, Addenbrookes Hospital, Cambridge UK (ADB, BJS), and the Dept. of Geriatric Medicine, Australian National University Medical School, Canberra, Australia (MMB). Send correspondence and reprint requests to Barbara J. Sahakian, Ph.D., University of Cambridge, School of Clinical Medicine, Dept. of Psychiatry, Box 189, Addenbrookes Hospital, Cambridge CB2 2QQ, UK.
© 2005 American Association for Geriatric Psychiatry

Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.

Key Words: Mild Cognitive Impairment • Dementia • Cognitive Status • Age-Associated Memory Impairment (AAMI)

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