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Subjective Memory Complaints With and Without Objective Memory Impairment

Relationship With Risk Factors for Dementia

Received October 14, 2004; revised January 17, 2005; accepted January 19, 2005. From the School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia (NTL, OPA), the Dept. of Biochemistry, Royal Perth Hospital, Perth, Australia (SV), the School of Medicine and Pharmacology, University of Western Australia (LF, PL), the Royal Perth Hospital Department of Endocrinology, Western Australian Institute for Medical Research (PL), and the Centre for Medical Research, University of Western Australia (PL). Send correspondence and reprint requests to Associate Professor Nicola T. Lautenschlager, UWA School of Psychiatry and Clinical Neurosciences (M573 – Level 6, Ainslie House, Royal Perth Hospital), 35 Stirling Highway, Crawley, Perth, WA 6009, Australia. e-mail: nicolal{at}cyllene.uwa.edu.au
© 2005 American Association for Geriatric Psychiatry

Objective: The authors investigated the frequency distribution of well-established risk factors for dementia—high plasma homocysteine and the apolipoprotein E 4 allele (APOE 4)—among older women with subjective memory complaints (SMC) but no cognitive impairment, and with mild cognitive impairment (MCI). Methods: This was a cross-sectional, community-based study. Results: Women with MCI had higher total plasma homocysteine than healthy-comparison subjects. There was also a nonsignificant excess of APOE 4 carriers in the MCI than in the healthy group. Participants with SMC had higher depression and anxiety scores than healthy-comparison subjects, but did not differ from subjects in the healthy-comparison group in relation to their total plasma homocysteine and APOE 4 distribution. Conclusions: MCI seems to be more closely related to well-established risk factors for dementia than is SMC.

Key Words: Dementia • Memory Complaints • Mild Cognitive Impairment • Homocysteine • Apolipoprotein E

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