HOME HELP FEEDBACK SUBSCRIPTIONS ALL ISSUES SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a Colleague Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Feldman, H. H. Articles by Jacova, C. Search for Related Content PubMed PubMed Citation Articles by Feldman, H. H. Articles by Jacova, C.

Mild Cognitive Impairment

Received December 14, 2004; revised March 31, 2005; accepted April 4, 2005. From the Division of Neurology, Dept. of Medicine, Clinic for Alzheimer Disease and Related Disorders, University of British Columbia, Vancouver, British Columbia, Canada. Send correspondence and reprint requests to Dr. Howard H. Feldman, Division of Neurology, Dept. of Medicine, Clinic for Alzheimer Disease and Related Disorders, University of British Columbia, S192-2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5. e-mail: hfeldman{at}interchange.ubc.ca
© 2005 American Association for Geriatric Psychiatry

ABSTRACT

Mild cognitive impairment (MCI) describes a state of cognitive functioning that is below defined norms, yet falls short of dementia in severity. It exists across a cognitive continuum with borders that are difficult to define precisely. Within our "graying" western societies, its prevalence increases with age. A number of subtypes of MCI, including age-associated memory impairment (AAMI), age-associated cognitive decline (AACD), amnestic MCI (MCIa), and cognitive impairment not dementia (CIND) have contributed to our understanding of MCI. Recent efforts have been directed at developing a uniform diagnostic classification for MCI that reflects the maturation of knowledge about this state. There is considerable etiological and clinical heterogeneity within MCI; however, there is a unifying increased risk of progression to dementia. The diagnostic process for MCI involves assessment of multiple cognitive domains, with particular attention to episodic and semantic memory, while neuroimaging with structural MRI and PET both add to the diagnostic and prognostic evaluation of MCI. Although there are no pharmacological treatments at present that are capable of delaying the long-term progression of MCI to dementia, there is some evidence of short-term symptomatic benefits with acetylcholinesterase inhibitors. MCI is an important clinical problem, which clinicians can expect to face with increasing frequency. The essentials of management include a thorough assessment directed at etiological determination and counseling and judicious use of available therapeutics.

Key Words: Mild Cognitive Impairment • Cognitive Status • Dementia • Age-Associated Memory Impairment (AAMI)

This article has been cited by other articles:

				K. Palmer, L. Backman, B. Winblad, and L. Fratiglioni Mild Cognitive Impairment in the General Population: Occurrence and Progression to Alzheimer Disease Am J Geriatr Psychiatry, July 1, 2008; 16(7): 603 - 611. [Abstract] [Full Text] [PDF]

				B. Winblad, S. Gauthier, L. Scinto, H. Feldman, G. K. Wilcock, L. Truyen, A. J. Mayorga, D. Wang, H. R. Brashear, J. S. Nye, et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment Neurology, May 27, 2008; 70(22): 2024 - 2035. [Abstract] [Full Text] [PDF]

				S. K. Das, P. Bose, A. Biswas, A. Dutt, T. K. Banerjee, A. Hazra, D. K. Raut, A. Chaudhuri, and T. Roy An epidemiologic study of mild cognitive impairment in Kolkata, India Neurology, June 5, 2007; 68(23): 2019 - 2026. [Abstract] [Full Text] [PDF]

				M. J DE LEON, L MOSCONI, K BLENNOW, S DESANTI, R ZINKOWSKI, P. D MEHTA, D PRATICO, W TSUI, L. A. S. LOUIS, L SOBANSKA, et al. Imaging and CSF Studies in the Preclinical Diagnosis of Alzheimer's Disease Ann. N.Y. Acad. Sci., February 1, 2007; 1097(1): 114 - 145. [Abstract] [Full Text] [PDF]

				R. Monastero, K. Palmer, C. Qiu, B. Winblad, and L. Fratiglioni Heterogeneity in Risk Factors for Cognitive Impairment, No Dementia: Population-Based Longitudinal Study From the Kungsholmen Project Am J Geriatr Psychiatry, January 1, 2007; 15(1): 60 - 69. [Abstract] [Full Text] [PDF]

				P. J. Visser, A. Kester, J. Jolles, and F. Verhey Ten-year risk of dementia in subjects with mild cognitive impairment. Neurology, October 10, 2006; 67(7): 1201 - 1207. [Abstract] [Full Text] [PDF]

				S. Studenski, M. C. Carlson, H. Fillit, W. T. Greenough, A. Kramer, and G. W. Rebok From Bedside to Bench: Does Mental and Physical Activity Promote Cognitive Vitality in Late Life? Sci. Aging Knowl. Environ., June 28, 2006; 2006(10): pe21 - pe21. [Abstract] [Full Text]

				L. S. Schneider Mild Cognitive Impairment Am J Geriatr Psychiatry, August 1, 2005; 13(8): 629 - 632. [Full Text] [PDF]