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Am J Geriatr Psychiatry 13:624-627, July 2005
© 2005 American Association for Geriatric Psychiatry

Brief Report

Heritability of Psychosis in Alzheimer Disease

Silviu-Alin Bacanu, Ph.D., Bernie Devlin, Ph.D., Kodavali V. Chowdari, Ph.D., Steven T. DeKosky, M.D., Vishwajit L. Nimgaonkar, M.D., Ph.D., and Robert A. Sweet, M.D.

Received June 4, 2004; revised September 7, October 8, 2004; accepted October 21, 2004. From the Dept. of Psychiatry, Univ. of Pittsburgh School of Medicine (SAB, BD, KVC, STD, VLN, RAS); GlaxoSmithKline Research and Development, Research Triangle Park, N.C. (SAB); and the Dept. of Neurology, Univ. of Pittsburgh School of Medicine (STD). Send correspondence to Robert A. Sweet, M.D., Dept. of Psychiatry, Univ. of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213. e-mail: sweetra{at}upmc.edu
© 2005 American Association for Geriatric Psychiatry

Objective: The authors have previously demonstrated familial clustering of psychotic symptoms in late-onset Alzheimer disease (LOAD+P) and sought to estimate and explore the nature of the heritability of LOAD+P. Methods: The heritability of LOAD+P, defined by single and multiple psychotic symptoms, was estimated with data from the National Institute of Mental Health AD Genetics Initiative. Results: The estimated heritability for LOAD+P defined by multiple psychotic symptoms was 61%; for LOAD+P defined by any occurrence of psychotic symptoms, it was 30%. Conclusion: Multiplicity of symptoms may represent a useful means for defining a genetically determined LOAD+P phenotype.

Key Words: Genetics • Psychosis • Alzheimer Disease




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