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Am J Geriatr Psychiatry 13:319-323, April 2005
© 2005 American Association for Geriatric Psychiatry

Brief Report

A Pilot Study of Standardized Treatment in Geriatric Bipolar Disorder

Ariel G. Gildengers, M.D., Benoit H. Mulsant, M.D., Amy E. Begley, M.A., Mary McShea, M.S., Jacqueline A. Stack, M.S.N., Mark D. Miller, M.D., Andrea Fagiolini, M.D., David J. Kupfer, M.D., Robert C. Young, M.D., and Charles F. Reynolds III, M.D.

Received October 17, 2004; revised November 15, 2004; accepted November 19, 2004. From the Intervention Research Center for Late-Life Mood Disorders, Dept. of Psychiatry, the Bipolar Disorder Center for Pennsylvanians, University of Pittsburgh School of Medicine (AGG, BHM,AEB,MM,JAS,MDM,AF,DJK,CFR), and the Department of Psychiatry at the Weill College of Medicine, Cornell University (RCY). Send correspondence and reprint requests to Dr. Mulsant, 3811 O’Hara St., Pittsburgh, PA 15213. e-mail address: mulsantbh{at}upmc.edu
© 2005 American Association for Geriatric Psychiatry

Objective: The authors sought to determine the feasibility of treating elderly adults with bipolar disorder under standardized-treatment conditions. Methods: Thirty-one patients age 60 and older with bipolar disorder were treated in standardized pathways. Mood state was checked at each study visit with the Hamilton Rating Scale for Depression–17 item (Ham-D–17) and the Young Mania Rating Scale (YMRS). Results: Defining "well days" as both Ham-D and YMRS scores of ≤10, the mean percentage of well days was 72.5 (range: 0%–100%) over study participation. Conclusions: Treating older adults with bipolar disorder under standardized treatment is feasible and is associated with low symptom levels. However, most older adults with bipolar disorder do not experience sustained recovery.

Key Words: Bipolar Disorder • Mood Disorder • Pharmacotherapy




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A. G. Gildengers, M. A. Butters, D. Chisholm, J. C. Rogers, M. B. Holm, R. K. Bhalla, K. Seligman, M. A. Dew, C. F. Reynolds III, D. J. Kupfer, et al.
Cognitive Functioning and Instrumental Activities of Daily Living in Late-Life Bipolar Disorder
Am J Geriatr Psychiatry, February 1, 2007; 15(2): 174 - 179.
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