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Hormone Replacement Therapy and Longitudinal Cognitive Performance in Postmenopausal Women

Received November 17, 2004; revised May 2, 2005; accepted June 4, 2005. From the Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA (ROH,CMS,CB,AMB,AMA,MSM,LFF,JAY) and the VA Palo Alto Health Care System, Palo Alto, CA (JAY). Send correspondence and reprint requests to Ruth O’Hara, Ph.D., Dept. of Psychiatry and Behavioral Sciences, Stanford Univ. School of Medicine, Stanford, CA 94305-5550. e-mail: roh{at}leland.stanford.edu
© 2005 American Association for Geriatric Psychiatry

Objective: The authors examined the impact of hormone replacement therapy (HRT) on longitudinal cognitive performance (controlling for mood state) in 69 community-dwelling, postmenopausal women. Methods: The authors conducted a 5-year follow-up of cognitive performance in 37 postmenopausal HRT users and 32 non-users. The groups did not differ with respect to age, years of education, or inter-test interval. Results: No main effect of HRT was observed on any of the cognitive measures, and depressive symptomatology did not affect the relationship between HRT and cognition. Conclusion: Overall, our findings do not suggest that HRT affects longitudinal cognitive performance in postmenopausal, community-dwelling older women.

Key Words: Hormone Replacement Therapy • Longitudinal Studies • Postmenopausal Women • Cognition • Dementia • Estrogen • Memory

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