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Am J Geriatr Psychiatry 13:910-913, October 2005
© 2005 American Association for Geriatric Psychiatry
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Brief Report

Hippocampal Volume as a Predictor of Short-Term ECT Outcomes in Older Patients With Depression

Ruby E. Lekwauwa, B.S., Douglas R. McQuoid, B.S., and David C. Steffens, M.D., M.H.S.

Received July 14, 2004; revised September 16, October 27, 2004; accepted November 8, 2004. From the Dept. of Psychiatry and Behavioral Sciences, Duke Univ. Medical Center, Durham, NC. Send correspondence and reprint requests to David C. Steffens, M.D., M.H.S., Associate Professor of Psychiatry and Medicine; Head, Division of Geriatric Psychiatry, Duke Univ. Medical Center, Box 3903, Durham, NC 27710. e-mail: steff001{at}mc.duke.edu
© 2005 American Association for Geriatric Psychiatry

Objective: The authors examined the relationship between hippocampal volume and acute electroconvulsive therapy (ECT) outcomes. Methods: Depression was measured by Montgomery-Asberg Depression Rating Scale (MADRS) scores, and hippocampal volume was assessed by magnetic resonance imaging. Results: After controlling for baseline MADRS score, larger right-hippocampal volume was associated with higher MADRS scores after an index course of ECT. Conclusion: These results are the converse of those obtained in a study assessing the relationship between hippocampal volume and pharmacotherapy. The findings suggest a need for further study in this area.

Key Words: Depression • ECT • MRI Studies • Hippocampal Volume




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D. C. Steffens
Research in Geriatric Depression: A Model for Mental Health Research in the 21st Century?
Am J Geriatr Psychiatry, October 1, 2005; 13(10): 829 - 833.
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