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Neural Basis for the Cognitive Continuum in Episodic Memory From Health to Alzheimer Disease

Received February 4, 2004; revised May 25, July 9, 2004; accepted July 16, 2004. From the Memory Clinic (GG,MWR), the Dept. of Psychiatry (GG), and the Dept. of Neurology (MWR), University of Ulm, Ulm, Germany. Send correspondence to Prof. Matthias W. Riepe, Department of Neurology, University of Ulm, Steinhoevelstr. 1, 89075 Ulm, Germany. e-mail: matthias.riepe{at}medizin.uni-ulm.de
© 2004 American Association for Geriatric Psychiatry

Objective: The authors hypothesize that, behaviorally, episodic memory in health and disease reflects a continuum. Methods: Subjects (N=12) with very mild Alzheimer disease (AD) and normal subjects (N=24) were investigated with functional magnetic resonance imaging (fMRI) during an episodic memory task. Results: Recruitment of a posterior medio-temporal network was correlated with memory performance across the spectrum from high- and low-performing normal subjects to patients with early AD. Conclusions: The behavioral spectrum from health to disease in episodic memory function is mirrored neurobiologically with graded recruitment of neuronal activation in medio-temporal regions. The results call for longitudinal assessment of behavioral decline and neuronal recruitment in future studies.

Key Words: MRI Studies • Neuroimaging • Volumetric Studies • Hippocampus • Neuroanatomy

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