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Lower Mortality in Geriatric Patients Receiving Risperidone and Olanzapine Versus Haloperidol

Preliminary Analysis of Retrospective Data

Received August 7, 2003; revised September 12, accepted September 22, 2003. From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, OH (HAN,ATN) and the VA Medical Center, Jackson, MS (TW). Send correspondence to Henry A. Nasrallah, M.D., Department of Psychiatry, University of Cincinnati Medical Center, 231 Albert Sabin Way, Cincinnati, OH 45267-0559. e-mail: henry.nasrallah{at}uc.edu
© 2004 American Association for Geriatric Psychiatry

Objective: The authors examined the mortality rate in geriatric patients receiving either haloperidol or atypical antipsychotics. Methods: Authors tracked mortality over a 2-year period in patients age 65 years or older receiving haloperidol (N=299) or the atypical antipsychotics risperidone or olanzapine (N= 1,254). Results: Sixty-four patients in the haloperidol group (21.4%) and 61 patients in the atypical group (4.75%) died during the 2-year study period. The difference was statistically significant. Conclusions: The findings suggest that mortality in elderly patients receiving haloperidol is significantly higher than in those receiving the atypical antipsychotics risperidone or olanzapine. Authors discuss possible causal mechanisms.

Key Words: Atypical Antipsychotics • Haloperidol • Outcome Studies • Risperidone • Olanzapine

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