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Mapping Behavioral Traits by Use of Genome-Tagged Mice

Received January 13, 2003; revised April 15, 2003; accepted May 13, 2003. From the Departments of Molecular and Medical Pharmacology and Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA. Address correspondence to Dr. Smith, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, 23-151 CHS, Box 951735, Los Angeles, CA 90095-1735. e-mail: DSmith{at}mednet.ucla.edu
© 2004 American Association for Geriatric Psychiatry

Objective: Complex trait mapping has been widely used to analyze the genetics of behavior. However, the approach has some disadvantages, including poor gene localization and low replicability. Genome-tagged mice (GTMs) are sets of congenic mouse strains that span the entire mouse genome and are a promising reagent for localization of genes contributing to behavior. Methods: In order to map behavioral loci of interest, a GTM was investigated in which the middle region of Chromosome 1 from DBA/2J was introgressed onto a C57BL/6J background. The GTM was analyzed for behaviors related to sensorimotor gating, anxiety, depression, pain sensitivity, and learning and memory. Results: The GTM was found to harbor a locus contributing to learning and memory, replicating results from complex trait analysis. Conclusions: The GTMs should be a valuable resource for mapping and confirmation of loci contributing to complex behavioral traits in the mouse, with ultimate implications for human genomic-based research, as well.

Key Words: Behavior Genetics • Congenics • Learning • Memory

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