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Frontal Behavioral Syndromes and Functional Status in Probable Alzheimer Disease

Received July 30, 2002; accepted April 3, 2003. From the Department of Psychology, Indiana University, Bloomington, IN (JCS,MFW,SAJ) and the Department of Neurosciences, Alzheimer's Disease Research Center, University of California, San Diego, CA (GMP,DPS). Address correspondence to Dr. Stout, Department of Psychology, Indiana University, 1101 E. 10th Street, Bloomington, IN 47405-7007. e-mail: jcstout{at}indiana.edu

Objective/Method: The authors used the Frontal Systems Behavior Scale (FrSBe) to determine the frequency of frontal behavioral syndromes in 49 subjects with mild-to-moderate dementia and 23 subjects with severe dementia of Alzheimer disease (AD) and 23 healthy control (HC) participants. Results/Conclusions: Frontal behavior syndromes occurred with higher frequency in AD. Apathy and executive dysfunction were elevated both in mild-to-moderate and severe AD. Disinhibition was elevated only in severe AD. In AD, apathy was associated with difficulty in basic activities of daily living (ADL), whereas executive dysfunction was related to impairment in instrumental ADLs.

Key Words: Frontal Behavioral Syndromes • Alzheimer Disease • Activities of Daily Living