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MRI Lesion Severity and Mortality in Geriatric Depression

Received March 25, 2002; accepted August 23, 2002. From the Department of Psychiatry and Behavioral Sciences (RML, DCS, DRM, KRR) and Radiology (JMP, JRM), Duke University Medical Center. Address correspondence to Dr. Steffens, Duke University Medical Center, Box 3903, Durham, NC 27710. e-mail: steff001{at}mc.duke.edu

Objective: The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients. Method: They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensity (PVH), and subcortical gray-matter hyperintensity (SGH) ratings in 259 subjects. Results: DWMH and PVH were significantly associated with mortality initially, and, in final modeling, DWMH remained significant. Conclusion: These findings suggest that there is a relationship between cerebrovascular disease severity and mortality among depressed patients. More studies, with larger sample sizes, comparing depressed patients and control subjects are needed to further elucidate this relationship.

Key Words: Depression • MRI • Syndromes Secondary to General Medical Disorders