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Am J Geriatr Psychiatry 10:344-347, June 2002
© 2002 American Association for Geriatric Psychiatry


Clinical and Research Reports

Citalopram Treatment of Minor Depression in Elderly Men

An Open Pilot Study

John W. Kasckow, M.D., Ph.D., Jeff Welge, Ph.D., Brendan T. Carroll, M.D., Arthur Thalassinos, M.D., and Sonia Mohamed, M.D., Ph.D.

Received January 18, 2001; revised June 6, 2001; accepted July 2, 2001. From the Department of Psychiatry, University of Cincinnati College of Medicine, and the Cincinnati VAMC, Cincinnati, OH. Address correspondence to Dr. Kasckow, Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way (ML559), Cincinnati, OH 45267-0559.

Antidepressant pharmacotherapy in elderly patients is challenging. The authors examined the use of citalopram to treat late-life minor depression. Ten men (mean age: 73±2 years) with DSM-IV Minor Depression were administered citalopram 20 mg/day. Efficacy was measured with the Geriatric Depression Scale (GDS), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Clinical Global Impressions of Severity (CGI-S) scales. Citalopram was well tolerated, and GDS, MADRS, and CGI-S scores decreased after 12 weeks. These findings indicate that citalopram is safe and effective in the treatment of late-life minor depression.

Key Words: Depression • Antidepressants • Minor Depression • Citalopram




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