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Stressful Life Events Interacting With Cognitive/Personality Styles to Predict Late-Onset Major Depression

Received August 23, 2001; revised December 19, 2001, January 9, 2002; accepted January 22, 2002. From Yale University School of Medicine, Department of Psychiatry, New Haven, CT (CMM, SCJ); Donaghue Women's Health Investigator Program at Yale (CMM, PKM); and Weill Medical College of Cornell University, Department of Psychiatry, White Plains, NY (MLB). Address correspondence to Dr. Mazure, Yale University School of Medicine, P.O. Box 208091, New Haven, CT 06520.

The current work evaluated the interaction of life stressors with cognitive/personality styles in predicting late-onset depression in 42 elderly outpatients with DSM-IV unipolar Major Depression and 42 nondepressed controls. Control subjects were matched to cases on age, sex, race, and years of education. As suggested by Beck's cognitive theory of depression, a multivariate model indicated that specific stressful-event types interacted with specific cognitive/personality styles in strongly predicting depression onset, adjusting for the positive associations of medical illness and reduced physical functioning with depression.

Key Words: Depression • Personality Factors • Stressful Events

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