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Special Article |
Received August 14, 2001; revised September 4, 2001; January 31, 2002; accepted September 6, 2001. From the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA. Address correspondence to Dr. Helen Lavretsky, UCLA-Neuropsychiatric Institute, Room 37-425, 760 Westwood Pl., Los Angeles CA 90095.
Clinically significant non-major depression has been underinvestigated despite its high prevalence and public health impact. Although there is an increasing recognition of the importance of non-major forms of depression, their nosological boundaries and neurobiological mechanisms remain largely unknown. The authors discuss the literature pertaining to the current concepts, phenomenology, neurobiology, and treatment approaches to geriatric non-major clinically significant depression. They examine the similarities and differences between various subtypes of depressive disorders and compare non-major, clinically significant depression in elderly patients with non-geriatric adult populations. They draw conclusions from the published literature and propose clinical criteria for the diagnosis of clinically significant non-major depression in elderly persons.
Key Words: Depression • Antidepressants • Special Articles • Subsyndromal Depression
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