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Special Article |
Received September 28, 2001; revised, accepted January 18, 2002. From the Adult and Geriatric Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Rockville, Maryland (Drs. Olin and Lebowitz). Address correspondence to Dr. Olin, National Institute of Mental Health, 6001 Executive Blvd., Room 7160 MSC 9635, Bethesda, MD 20892-9635. e-mail: jolin{at}mail.nih.gov
This review provides the rationale and background for the development of diagnostic criteria for depression of Alzheimer disease (AD), including risk factors and neurobiological correlates, epidemiology, and clinical characteristics, along with course, assessment, treatment, economics, a description of the criteria, and future research directions. Overall, there is substantial research to suggest that the depression that may co-occur with AD is different from other depressive disorders. Further research is needed to better define core symptoms, clinical course, and efficacy of treatments.
Key Words: Depression of AD • Diagnostic Criteria
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