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Functional MRI and Novel Picture-Learning Among Older Patients With Chronic Schizophrenia

Abnormal Correlations Between Recognition Memory and Medial Temporal Brain Response

Received June 14, 2001; revised August 20, September 20, 2001; accepted September 25, 2001. From the Mental Illness Research, Education and Clinical Center, Veterans Affairs San Diego Healthcare System, and the Department of Psychiatry, University of California, San Diego. Address correspondence to Dr. Brown, Psychology Service (116B), VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA 92161. e-mail: gbrown{at}ucsd.edu

The relationship between disordered brain function and learning deficits in chronic schizophrenia is unclear. The authors compared correlations of brain response to picture encoding with subsequent recognition memory between samples of clinically stable patients over age 45 with schizophrenia and demographically similar healthy individuals. Subjects were studied with functional magnetic resonance imaging during novel picture encoding and a control condition. Comparison subjects showed an inverse relationship between subsequent recognition memory and brain response in medial temporal areas. Among schizophrenia patients, brain response in these regions was positively correlated with recognition memory. Brain–behavior relationships during learning were thus found to be qualitatively different between schizophrenic patients and healthy subjects.

Key Words: fMR • Schizophrenia Spectrum Disorder • Neuroimaging • Frontal Lobe

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