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Am J Geriatr Psychiatry 10:107-111, February 2002
© 2002 American Association for Geriatric Psychiatry

Brief Report

The Relationship of MRI Subcortical Hyperintensities to Treatment Response in a Trial of Sertraline in Geriatric Depressed Outpatients

Stephen Salloway, M.D., M.S., Patricia A. Boyle, Ph.D., Stephen Correia, Ph.D., Paul F. Malloy, Ph.D., Deborah A. Cahn-Weiner, Ph.D., Lon Schneider, M.D., K. Ranga Rama Krishnan, M.D., and Raj Nakra, M.D.

Received June 19, 2001; revised September 20, October 2, 2001; accepted October 4, 2001. From the Department of Neurology, Butler Hospital, Providence, Rhode Island. Address correspondence to Dr. Salloway, Department of Neurology, Butler Hospital, 345 Blackstone Blvd., Providence, RI 02906. E-mail: Stephen_Salloway{at}Brown.edu

The authors examined differences in antidepressant treatment response in geriatric outpatients with high vs. low levels of magnetic resonance imaging (MRI)-defined subcortical hyperintensities (SH). Participants included 59 outpatients with mild-to-moderate depression (mean age: 69±5.63 years; mean Hamilton Rating Scale for Depression score: 21±2.88) who participated in a placebo-controlled trial of sertraline and underwent a standardized brain MRI. Results revealed that the high-SH group was significantly older than the low-SH group but, contrary to the hypothesis, antidepressant treatment response did not differ between the high- and low-SH groups. The association between SH and antidepressant treatment response in depressed geriatric outpatients remains unclear and deserves further investigation.

Key Words: Depression Treatment • MRI • Subcortical Hyperintensities • Sertraline • Vascular Depression




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