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Frontal Release Signs and Their Relationship With the Initiation and Perseveration Component of the Mattis Dementia Rating Scale in Persons With Dementia

From the Departments of Neurology and Psychiatric Medicine, University of Virginia School of Medicine, Charlottesville, Virginia; Western State Hospital, Staunton, Virginia; and Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia

As part of a longitudinal study of dementia, 35 elderly patients with dementia were studied, correlating frontal release signs and performance on components of the Mattis Dementia Rating Scale. A frontal release score was developed using glabellar, palmar grasp, plantar grasp, and palmomental signs. There was a direct relationship between the frontal release score and the Initiation and Perseveration component of the Mattis Dementia Rating Scale. This relationship persisted between isolated glabellar sign findings and the Initiation and Perseveration component of the Mattis Dementia Rating Scale. These findings are highly preliminary. Refining frontal release sign testing and frontal lobe mental status testing may strengthen their relationship and lead to a better understanding of dementia and its progression.